Five research peptides compared
A US draft policy from the Department of Health and Human Services (HHS) names six peptides. This page sets out what each is as a molecule and what the policy documents say about the evidence. It does not alter UK rules, which are covered in is BPC-157 legal in the UK.
What is each of the six peptides?
| Peptide | What it is |
|---|---|
| BPC-157 | Synthetic 15-amino-acid peptide derived from a gastric protein sequence |
| TB-500 | Synthetic 7-amino-acid fragment of thymosin beta-4 (Ac-LKKTETQ) |
| MOTS-c | 16-amino-acid peptide encoded in mitochondrial DNA |
| KPV | Lys-Pro-Val, a three-amino-acid fragment of alpha-melanocyte-stimulating hormone |
| Semax | Synthetic heptapeptide analogue of an ACTH fragment, with a Pro-Gly-Pro tail |
| Epitalon | Synthetic tetrapeptide (Ala-Glu-Asp-Gly) |
TB-500 is a short fragment, not thymosin beta-4 itself, which is a 43-amino-acid protein.
What did HHS say about the evidence?
HHS described FDA scientists' concerns about TB-500, Epitalon and Semax as "inferential or mechanistic rather than observed", and for KPV as reflecting "an absence of information". FDA briefing materials called the BPC-157 studies limited in size and duration, without establishing safety or effectiveness.
EPS documentation
Use the research catalogue to check the exact name, labelled amount and format. The COA library publishes the original Janoshik reports selected for EPS, retaining the original report client name and any missing batch fields. Literature findings and another supplier's analytical results are not evidence about an EPS batch.
